› 1yjp

X-ray diffraction
1.8Å resolution

Structure of GNNQQNY from yeast prion Sup35

Released:
DOI: 10.2210/pdb1yjp/pdb
PDB entry 1yjp coloured by chain, front view.
PDB entry 1yjp coloured by chain, side view.
PDB entry 1yjp coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
Structure of the cross-beta spine of amyloid-like fibrils.
Nelson R, Sawaya MR, Balbirnie M, Madsen AØ, Riekel C, Grothe R, Eisenberg D
Nature 435 773-8 (2005)
PMID: 15944695

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic peptide chain release factor GTP-binding subunit Chain: A
Molecule details ›
Chain: A
Length: 7 amino acids
Theoretical weight: 837 Da
Source organism: Saccharomyces cerevisiae S288C
Expression system: Not provided
UniProt:
  • Canonical: P05453 (Residues: 7-13; Coverage: 1%)
Gene names: GST1, PNM2, SAL3, SUF12, SUP2, SUP35, YD9395.05, YDR172W

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P21
Unit cell:
a: 21.937Å b: 4.866Å c: 23.477Å
α: 90° β: 107.08° γ: 90°
R-values:
R R work R free
0.181 0.181 0.19
Expression system: Not provided

Quick links

Citations

305 review citations

Protein misfolding, functional amyloid, and human disease.
Chiti et al. (2006)
304 more

40 mentions without citation

Structural polymorphism of Alzheimer Abeta and other amyloid fibrils.
Fändrich et al. (2009)
39 more