› 1y7n

Solution NMR

Solution structure of the second PDZ domain of the human neuronal adaptor X11alpha

Released:
DOI: 10.2210/pdb1y7n/pdb
PDB entry 1y7n coloured by chain, ensemble of 20 models, front view.
PDB entry 1y7n coloured by chain, ensemble of 20 models, side view.
PDB entry 1y7n coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the second PDZ domain of the neuronal adaptor X11alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase.
Duquesne AE, Ruijter Md, Brouwer J, Drijfhout JW, Nabuurs SB, Spronk CA, Vuister GW, Ubbink M, Canters GW
J Biomol NMR 32 209-18 (2005)
PMID: 16132821

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta A4 precursor protein-binding family A member 1 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 9.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02410 (Residues: 745-823; Coverage: 9%)
Gene names: APBA1, MINT1, X11
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics simulation, torsion angle dynamics, distance and dihedral angle restraints
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The X11 proteins, Abeta production and Alzheimer's disease.
Miller et al. (2006)
1 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)