› 1x48

Solution NMR

Solution structure of the second DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase

Released:
DOI: 10.2210/pdb1x48/pdb
PDB entry 1x48 coloured by chain, ensemble of 20 models, front view.
PDB entry 1x48 coloured by chain, ensemble of 20 models, side view.
PDB entry 1x48 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Entry authors: He F, Muto Y, Inoue M, Tarada T, Shirouzu M, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169954 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-induced, double-stranded RNA-activated protein kinase Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 9.27 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q03963 (Residues: 96-170; Coverage: 15%)
Gene names: Eif2ak2, Pkr, Prkr, Tik
Sequence domains: Double-stranded RNA binding motif
Structure domains: Double Stranded RNA Binding Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

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