› 1wwc

X-ray diffraction
1.9Å resolution

NT3 BINDING DOMAIN OF HUMAN TRKC RECEPTOR

Released:
DOI: 10.2210/pdb1wwc/pdb
PDB entry 1wwc coloured by chain, front view.
PDB entry 1wwc coloured by chain, side view.
PDB entry 1wwc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
Ultsch MH, Wiesmann C, Simmons LC, Henrich J, Yang M, Reilly D, Bass SH, de Vos AM
J Mol Biol 290 149-59 (1999)
PMID: 10388563

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-172460 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NT-3 growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 13.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16288 (Residues: 297-422; Coverage: 15%)
Gene names: NTRK3, TRKC
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P3221
Unit cell:
a: 82.9Å b: 82.9Å c: 30.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.187 0.288
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Neurotrophins: roles in neuronal development and function.
Huang et al. (2001)
29 more

8 mentions without citation

Identification of hot-spot residues in protein-protein interactions by computational docking.
Grosdidier et al. (2008)
7 more