› 1wtl

X-ray diffraction
1.9Å resolution

COMPARISON OF CRYSTAL STRUCTURES OF TWO HOMOLOGOUS PROTEINS: STRUCTURAL ORIGIN OF ALTERED DOMAIN INTERACTIONS IN IMMUNOGLOBULIN LIGHT CHAIN DIMERS

Released:
DOI: 10.2210/pdb1wtl/pdb
PDB entry 1wtl coloured by chain, front view.
PDB entry 1wtl coloured by chain, side view.
PDB entry 1wtl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Comparison of crystal structures of two homologous proteins: structural origin of altered domain interactions in immunoglobulin light-chain dimers.
Huang DB, Chang CH, Ainsworth C, Brünger AT, Eulitz M, Solomon A, Stevens FJ, Schiffer M
Biochemistry 33 14848-57 (1994)
PMID: 7993911

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134439 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin kappa variable 1D-33 Chains: A, B
Molecule details ›
Chains: A, B
Length: 108 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01593 (Residues: 23-117; Coverage: 100%)
Gene name: IGKV1D-33
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P64
Unit cell:
a: 82.25Å b: 82.25Å c: 61.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.157 not available not available
Expression system: Not provided

Quick links

Citations

2 review citations

Amyloid formation in light chain amyloidosis.
Ramirez-Alvarado M. (2012)
1 more

2 mentions without citation

Light chain amyloidosis - current findings and future prospects.
Baden et al. (2009)
1 more