› 1wak

X-ray diffraction
1.73Å resolution

X-ray structure of SRPK1

Released:
DOI: 10.2210/pdb1wak/pdb
PDB entry 1wak coloured by chain, front view.
PDB entry 1wak coloured by chain, side view.
PDB entry 1wak coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
SR protein kinase 1 is resilient to inactivation.
Ngo JC, Gullingsrud J, Giang K, Yeh MJ, Fu XD, Adams JA, McCammon JA, Ghosh G
Structure 15 123-33 (2007)
PMID: 17223538

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SRSF protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 397 amino acids
Theoretical weight: 45.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96SB4 (Residues: 42-655; Coverage: 61%)
Gene name: SRPK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6522
Unit cell:
a: 75.113Å b: 75.113Å c: 313.33Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.198 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Phosphorylation mechanism and structure of serine-arginine protein kinases.
Ghosh et al. (2011)
4 more

8 mentions without citation

Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa.
Talevich et al. (2011)
7 more