› 1urv

X-ray diffraction
2Å resolution

Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination

Released:
DOI: 10.2210/pdb1urv/pdb
PDB entry 1urv coloured by chain, front view.
PDB entry 1urv coloured by chain, side view.
PDB entry 1urv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination.
de Sanctis D, Dewilde S, Pesce A, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M
J Mol Biol 336 917-27 (2004)
PMID: 15095869

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186754 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoglobin Chains: A, B
Molecule details ›
Chains: A, B
Length: 190 amino acids
Theoretical weight: 21.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WWM9 (Residues: 1-190; Coverage: 100%)
Gene names: CYGB, STAP
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

2 bound ligands:
Ligand HEM 2 x HEM
Ligand FC6 2 x FC6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: P212121
Unit cell:
a: 48.94Å b: 70.429Å c: 100.913Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.219 0.265
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Structure and reactivity of hexacoordinate hemoglobins.
Kakar et al. (2010)
17 more

4 mentions without citation

The role of globins in cardiovascular physiology.
Keller et al. (2022)
3 more