› 1tt1

X-ray diffraction
1.93Å resolution

CRYSTAL STRUCTURE OF THE GLUR6 LIGAND BINDING CORE IN COMPLEX WITH KAINATE 1.93 A RESOLUTION

Released:
DOI: 10.2210/pdb1tt1/pdb
PDB entry 1tt1 coloured by chain, front view.
PDB entry 1tt1 coloured by chain, side view.
PDB entry 1tt1 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity.
Mayer ML
Neuron 45 539-52 (2005)
PMID: 15721240

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 259 amino acids
Theoretical weight: 29.37 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P42260 (Residues: 429-806; Coverage: 29%)
Gene names: Glur6, Grik2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand KAI 2 x KAI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-002
Spacegroup: P21
Unit cell:
a: 46.682Å b: 106.228Å c: 57.665Å
α: 90° β: 101.38° γ: 90°
R-values:
R R work R free
0.191 0.189 0.216
Expression system: Escherichia coli

Quick links

Citations

39 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
38 more

15 mentions without citation

Variability in docking success rates due to dataset preparation.
Corbeil et al. (2012)
14 more