› 1tqd

X-ray diffraction
2.3Å resolution

Crystal structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases

Released:
DOI: 10.2210/pdb1tqd/pdb
PDB entry 1tqd coloured by chain, front view.
PDB entry 1tqd coloured by chain, side view.
PDB entry 1tqd coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases.
Ghosh A, Uthaiah R, Howard J, Herrmann C, Wolf E
Mol Cell 15 727-39 (2004)
PMID: 15350217

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193063 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-inducible GTPase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 413 amino acids
Theoretical weight: 47.63 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9QZ85 (Residues: 1-413; Coverage: 100%)
Gene names: Iigp1, Irga6
Sequence domains: Interferon-inducible GTPase (IIGP)
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand MES 1 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14, ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 83.071Å b: 93.67Å c: 139.848Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.214 0.258
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

19 review citations

Structure-function relationships of the G domain, a canonical switch motif.
Wittinghofer et al. (2011)
18 more

2 mentions without citation

The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii.
Pawlowski et al. (2011)
1 more