› 1sxr

X-ray diffraction
1.56Å resolution

Drosophila Peptidoglycan Recognition Protein (PGRP)-SA

Released:
DOI: 10.2210/pdb1sxr/pdb
PDB entry 1sxr coloured by chain, front view.
PDB entry 1sxr coloured by chain, side view.
PDB entry 1sxr coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution.
Reiser JB, Teyton L, Wilson IA
J Mol Biol 340 909-17 (2004)
PMID: 15223330

Function and Biology Details

Reaction catalysed: 
GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H(2)O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-194326 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidoglycan-recognition protein SA Chains: A, B
Molecule details ›
Chains: A, B
Length: 183 amino acids
Theoretical weight: 20.3 KDa
Source organism: Drosophila melanogaster
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9VYX7 (Residues: 27-203; Coverage: 100%)
Gene names: CG11709, PGRP-SA, seml
Sequence domains: N-acetylmuramoyl-L-alanine amidase
Structure domains: Peptidoglycan recognition protein-like

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2
Unit cell:
a: 136.29Å b: 64.42Å c: 45.87Å
α: 90° β: 100.33° γ: 90°
R-values:
R R work R free
0.181 0.177 0.211
Expression system: Drosophila melanogaster

Quick links

Citations

9 review citations

The host defense of Drosophila melanogaster.
Lemaitre et al. (2007)
8 more

2 mentions without citation

The peptidoglycan recognition proteins (PGRPs).
Dziarski et al. (2006)
1 more