› 1sn2

X-ray diffraction
1.75Å resolution

Crystal Structure of Sea Bream Transthyretin at 1.90A Resolution

Released:
DOI: 10.2210/pdb1sn2/pdb
PDB entry 1sn2 coloured by chain, front view.
PDB entry 1sn2 coloured by chain, side view.
PDB entry 1sn2 coloured by chain, top view.
Source organism: Sparus aurata
Primary publication:
High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine.
Eneqvist T, Lundberg E, Karlsson A, Huang S, Santos CR, Power DM, Sauer-Eriksson AE
J Biol Chem 279 26411-6 (2004)
PMID: 15082720

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192947 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 130 amino acids
Theoretical weight: 14.03 KDa
Source organism: Sparus aurata
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9PTT3 (Residues: 22-151; Coverage: 99%)
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P41
Unit cell:
a: 58.497Å b: 58.497Å c: 140.71Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.175 0.21
Expression system: Escherichia coli

Quick links

Citations

8 review citations

The Halogen Bond.
Cavallo et al. (2016)
7 more

2 mentions without citation

Stretching to understand proteins - a survey of the protein data bank.
SuĊ‚kowska et al. (2008)
1 more