› 1shx

X-ray diffraction
2.1Å resolution

Ephrin A5 ligand structure

Released:
DOI: 10.2210/pdb1shx/pdb
PDB entry 1shx coloured by chain, front view.
PDB entry 1shx coloured by chain, side view.
PDB entry 1shx coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3.
Day B, To C, Himanen JP, Smith FM, Nikolov DB, Boyd AW, Lackmann M
J Biol Chem 280 26526-32 (2005)
PMID: 15901737

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126623 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Ephrin-A5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 16.32 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: O08543 (Residues: 28-165; Coverage: 66%)
Gene names: Efna5, Epl7, Eplg7, Lerk7
Sequence domains: Ephrin
Structure domains: Cupredoxins - blue copper proteins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A
Spacegroup: P21
Unit cell:
a: 36.21Å b: 70.08Å c: 58.46Å
α: 90° β: 95.94° γ: 90°
R-values:
R R work R free
0.224 0.224 0.278
Expression system: Homo sapiens

Quick links

Citations

10 review citations

Cell-cell signaling via Eph receptors and ephrins.
Himanen et al. (2007)
9 more

2 mentions without citation

Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis.
Li et al. (2019)
1 more