› 1s50

X-ray diffraction
1.65Å resolution

X-ray structure of the GluR6 ligand binding core (S1S2A) in complex with glutamate at 1.65 A resolution

Released:
DOI: 10.2210/pdb1s50/pdb
PDB entry 1s50 coloured by chain, front view.
PDB entry 1s50 coloured by chain, side view.
PDB entry 1s50 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity.
Mayer ML
Neuron 45 539-52 (2005)
PMID: 15721240

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154583 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chain: A
Molecule details ›
Chain: A
Length: 259 amino acids
Theoretical weight: 29.37 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P42260 (Residues: 429-806; Coverage: 29%)
Gene names: Glur6, Grik2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand GLU 1 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P61
Unit cell:
a: 52.272Å b: 52.272Å c: 169.411Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.2 0.23
Expression system: Escherichia coli

Quick links

Citations

38 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
37 more

14 mentions without citation

The structure and function of glutamate receptors: Mg2+ block to X-ray diffraction.
Mayer ML. (2017)
13 more