› 1rwl

X-ray diffraction
1.9Å resolution

Extracellular domain of Mycobacterium tuberculosis PknD

Released:
DOI: 10.2210/pdb1rwl/pdb
PDB entry 1rwl coloured by chain, front view.
PDB entry 1rwl coloured by chain, side view.
PDB entry 1rwl coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller.
Good MC, Greenstein AE, Young TA, Ng HL, Alber T
J Mol Biol 339 459-69 (2004)
PMID: 15136047

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PknD Chain: A
Molecule details ›
Chain: A
Length: 270 amino acids
Theoretical weight: 28.52 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WI79 (Residues: 403-664; Coverage: 40%)
Gene names: MTCY08C9.08, Rv0931c, pknD
Sequence domains: NHL repeat
Structure domains: TolB, C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand CD 4 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 43.94Å b: 94.58Å c: 71.77Å
α: 90° β: 98.1° γ: 90°
R-values:
R R work R free
0.216 0.214 0.262
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Eukaryote-like serine/threonine kinases and phosphatases in bacteria.
Pereira et al. (2011)
4 more

11 mentions without citation

Mycobacterium tuberculosis Serine/Threonine Protein Kinases.
Prisic et al. (2014)
10 more