› 1reu

X-ray diffraction
2.65Å resolution

Structure of the bone morphogenetic protein 2 mutant L51P

Released:
DOI: 10.2210/pdb1reu/pdb
PDB entry 1reu coloured by chain, front view.
PDB entry 1reu coloured by chain, side view.
PDB entry 1reu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular recognition of BMP-2 and BMP receptor IA.
Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD
Nat Struct Mol Biol 11 481-8 (2004)
PMID: 15064755

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-146279 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone morphogenetic protein 2 Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 11.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12643 (Residues: 294-396; Coverage: 28%)
Gene names: BMP2, BMP2A
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand MPD 2 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: R32
Unit cell:
a: 94.292Å b: 94.292Å c: 102.882Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.215 0.235
Expression system: Escherichia coli

Quick links

Citations

31 review citations

Specificity and versatility in tgf-beta signaling through Smads.
Feng et al. (2005)
30 more

9 mentions without citation

Mechanical strength of 17,134 model proteins and cysteine slipknots.
Sikora et al. (2009)
8 more