› 1r6n

X-ray diffraction
2.4Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137321 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulatory protein E2 Chain: A
Molecule details ›
Chain: A
Length: 211 amino acids
Theoretical weight: 24.43 KDa
Source organism: human papillomavirus 11
Expression system: Escherichia coli
UniProt:
  • Canonical: P04015 (Residues: 2-201; Coverage: 55%)
Gene name: E2
Sequence domains: E2 (early) protein, N terminal
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand 434 2 x 434
Ligand ALQ 1 x ALQ
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P41
Unit cell:
a: 60.456Å b: 60.456Å c: 82.526Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.266
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
Wells et al. (2007)
11 more

23 mentions without citation

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.
Arkin et al. (2014)
22 more