› 1qqg

X-ray diffraction
2.3Å resolution

CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1

Released:
DOI: 10.2210/pdb1qqg/pdb
PDB entry 1qqg coloured by chain, front view.
PDB entry 1qqg coloured by chain, side view.
PDB entry 1qqg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Dhe-Paganon S, Ottinger EA, Nolte RT, Eck MJ, Shoelson SE
Proc Natl Acad Sci U S A 96 8378-83 (1999)
PMID: 10411883

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152953 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin receptor substrate 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 264 amino acids
Theoretical weight: 29.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35568 (Residues: 4-267; Coverage: 21%)
Gene name: IRS1
Sequence domains:
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-13
Spacegroup: P65
Unit cell:
a: 120.439Å b: 120.439Å c: 79.598Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.191 0.247
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains.
Lemmon et al. (2000)
15 more

13 mentions without citation

Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains.
Balaji et al. (2005)
12 more