Function and Biology Details
Reaction catalysed:
(1a) 2 L-arginine + 2 NADPH + 2 O(2) = 2 N(omega)-hydroxy-L-arginine + 2 NADP(+) + 2 H(2)O
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Nitric oxide synthase 1 and Alpha-1-syntrophin (preferred)
PDBe Complex ID:
PDB-CPX-151519 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Alpha-1-syntrophin
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 9.64 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Length: 90 amino acids
Theoretical weight: 9.64 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q61234 (Residues: 75-164; Coverage: 18%)
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Nitric oxide synthase 1
Molecule details ›
Chain: B
Length: 115 amino acids
Theoretical weight: 12.37 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Length: 115 amino acids
Theoretical weight: 12.37 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical: P29476 (Residues: 12-126; Coverage: 8%)
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRL BEAMLINE BL7-1, ALS BEAMLINE 5.0.2
Spacegroup:
P212121
Expression system: Escherichia coli
