› 1q0h

X-ray diffraction
2.2Å resolution

Function and Biology Details

Reaction catalysed: 
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155316 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-deoxy-D-xylulose 5-phosphate reductoisomerase Chain: A
Molecule details ›
Chain: A
Length: 406 amino acids
Theoretical weight: 45.3 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45568 (Residues: 1-398; Coverage: 100%)
Gene names: JW0168, b0173, dxr, ispC, yaeM
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NDP 1 x NDP
2 bound ligands:
Ligand FOM 1 x FOM
Ligand CIT 1 x CIT
1 modified residue:
Ligand MSE 19 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P3121
Unit cell:
a: 109.168Å b: 109.168Å c: 90.63Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.187 0.212
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling.
Płóciennikowska et al. (2015)
13 more