› 1poz

Solution NMR

SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44

Released:
DOI: 10.2210/pdb1poz/pdb
PDB entry 1poz coloured by chain, ensemble of 20 models, front view.
PDB entry 1poz coloured by chain, ensemble of 20 models, side view.
PDB entry 1poz coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.
Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG
Mol Cell 13 483-96 (2004)
PMID: 14992719

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147592 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD44 antigen Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 17.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P16070 (Residues: 20-178; Coverage: 22%)
Gene names: CD44, LHR, MDU2, MDU3, MIC4
Sequence domains: Extracellular link domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics simulated annealing refinement by molecular dynamics
Expression system: Escherichia coli

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Citations

32 review citations

Hyaluronan as an immune regulator in human diseases.
Jiang et al. (2011)
31 more

7 mentions without citation

Three-dimensional structural aspects of protein-polysaccharide interactions.
Nagae et al. (2014)
6 more