› 1ofz

X-ray diffraction
1.5Å resolution

Crystal structure of fungal lectin : six-bladed beta-propeller fold and novel fucose recognition mode for aleuria aurantia lectin

Released:
DOI: 10.2210/pdb1ofz/pdb
PDB entry 1ofz coloured by chain, front view.
PDB entry 1ofz coloured by chain, side view.
PDB entry 1ofz coloured by chain, top view.
Source organism: Aleuria aurantia
Primary publication:
Crystal structure of fungal lectin: six-bladed beta-propeller fold and novel fucose recognition mode for Aleuria aurantia lectin.
Wimmerova M, Mitchell E, Sanchez JF, Gautier C, Imberty A
J Biol Chem 278 27059-67 (2003)
PMID: 12732625

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148469 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fucose-specific lectin Chains: A, B
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 33.45 KDa
Source organism: Aleuria aurantia
UniProt:
  • Canonical: P18891 (Residues: 2-313; Coverage: 100%)
Sequence domains: Fungal fucose-specific lectin
Structure domains: Fucose-specific lectin

Ligands and Environments

2 bound ligands:
Ligand FUL 8 x FUL
Ligand FUC 4 x FUC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 45.969Å b: 86.406Å c: 77.849Å
α: 90° β: 90.62° γ: 90°
R-values:
R R work R free
0.144 0.144 0.179

Quick links

Citations

13 review citations

High-sensitivity analytical approaches for the structural characterization of glycoproteins.
Alley et al. (2013)
12 more

6 mentions without citation

Mushroom lectins: specificity, structure and bioactivity relevant to human disease.
Hassan et al. (2015)
5 more