Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
- Glycoprotein E, immunoglobulin-like domain, flavivirus
- Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily
- Immunoglobulin E-set
- Flaviviral glycoprotein E, central domain, subdomain 1
- Flaviviral glycoprotein E, central domain, subdomain 2
- Flaviviral glycoprotein E, dimerisation domain
- Envelope glycoprotein E, central and dimerisation domain, flavivirus
- Flavivirus glycoprotein, central and dimerisation domain superfamily
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
RNA-directed RNA polymerase NS5 (preferred)
PDBe Complex ID:
PDB-CPX-146330 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Envelope protein E
Molecule details ›
Chains: A, B
Length: 394 amino acids
Theoretical weight: 43.82 KDa
Source organism: Dengue virus 2
Expression system: Drosophila melanogaster
UniProt:
Length: 394 amino acids
Theoretical weight: 43.82 KDa
Source organism: Dengue virus 2
Expression system: Drosophila melanogaster
UniProt:
- Canonical:
P12823 (Residues: 281-674; Coverage: 12%)
- Flavivirus glycoprotein, central and dimerisation domains
- Flavivirus glycoprotein, immunoglobulin-like domain
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
CHESS BEAMLINE F1
Spacegroup:
P3121
Expression system: Drosophila melanogaster
