1npo

X-ray diffraction
3Å resolution

BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN

Released:
Source organism: Bos taurus
Primary publication:
Crystal structure of the neurophysin-oxytocin complex.
Nat Struct Biol 3 163-9 (1996)
PMID: 8564543

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
hetero octamer
PDBe Complex ID:
PDB-CPX-134089 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Neurophysin 2 Chain: A
Molecule details ›
Chain: A
Length: 95 amino acids
Theoretical weight: 9.89 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P01180 (Residues: 32-126; Coverage: 65%)
Gene name: AVP
Sequence domains: Neurohypophysial hormones, C-terminal Domain
Structure domains: Neurohypophysial hormone domain
OXYTOCIN Chains: B, D
Molecule details ›
Chains: B, D
Length: 9 amino acids
Theoretical weight: 1.01 KDa
Neurophysin 2 Chain: C
Molecule details ›
Chain: C
Length: 95 amino acids
Theoretical weight: 9.83 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P01180 (Residues: 32-126; Coverage: 65%)
Gene name: AVP
Sequence domains: Neurohypophysial hormones, C-terminal Domain
Structure domains: Neurohypophysial hormone domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P41212
Unit cell:
a: 69.05Å b: 69.05Å c: 113.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.182 0.266