› 1nob

X-ray diffraction
2.6Å resolution

KNOB DOMAIN FROM ADENOVIRUS SEROTYPE 12

Released:
DOI: 10.2210/pdb1nob/pdb
PDB entry 1nob coloured by chain, front view.
PDB entry 1nob coloured by chain, side view.
PDB entry 1nob coloured by chain, top view.
Source organism: Human adenovirus 12
Primary publication:
Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR.
Bewley MC, Springer K, Zhang YB, Freimuth P, Flanagan JM
Science 286 1579-83 (1999)
PMID: 10567268

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153214 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fiber protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 185 amino acids
Theoretical weight: 19.94 KDa
Source organism: Human adenovirus 12
Expression system: Escherichia coli
UniProt:
  • Canonical: P36711 (Residues: 403-587; Coverage: 32%)
Gene name: L5
Sequence domains: Adenoviral fibre protein (knob domain)
Structure domains: Adenovirus pIV-related, attachment domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 61.91Å b: 104.82Å c: 77.19Å
α: 90° β: 96.9° γ: 90°
R-values:
R R work R free
0.24 0.24 0.29
Expression system: Escherichia coli

Quick links

Citations

60 review citations

Virus entry: molecular mechanisms and biomedical applications.
Dimitrov DS. (2004)
59 more

4 mentions without citation

Protein-protein docking benchmark version 3.0.
Hwang et al. (2008)
3 more