› 1mqh

X-ray diffraction
1.8Å resolution

Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Bromo-Willardiine at 1.8 Angstroms Resolution

Released:
DOI: 10.2210/pdb1mqh/pdb
PDB entry 1mqh coloured by chain, front view.
PDB entry 1mqh coloured by chain, side view.
PDB entry 1mqh coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for partial agonist action at ionotropic glutamate receptors.
Jin R, Banke TG, Mayer ML, Traynelis SF, Gouaux E
Nat Neurosci 6 803-10 (2003)
PMID: 12872125

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.16 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand BWD 1 x BWD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21212
Unit cell:
a: 63.786Å b: 91.851Å c: 48.377Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.198 0.231
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

46 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
45 more

4 mentions without citation

Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution.
Maltsev et al. (2008)
3 more