› 1m5f

X-ray diffraction
1.95Å resolution

X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH ACPA AT 1.95 A RESOLUTION

Released:
DOI: 10.2210/pdb1m5f/pdb
PDB entry 1m5f coloured by chain, front view.
PDB entry 1m5f coloured by chain, side view.
PDB entry 1m5f coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.
Hogner A, Kastrup JS, Jin R, Liljefors T, Mayer ML, Egebjerg J, Larsen IK, Gouaux E
J Mol Biol 322 93-109 (2002)
PMID: 12215417

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148610 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 263 amino acids
Theoretical weight: 29.21 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand ZN 6 x ZN
Ligand AM1 3 x AM1
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21212
Unit cell:
a: 113.744Å b: 163.4Å c: 47.084Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.23
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
20 more