› 1m5d

X-ray diffraction
1.73Å resolution

X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH Br-HIBO AT 1.73 A RESOLUTION

Released:
DOI: 10.2210/pdb1m5d/pdb
PDB entry 1m5d coloured by chain, front view.
PDB entry 1m5d coloured by chain, side view.
PDB entry 1m5d coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.
Hogner A, Kastrup JS, Jin R, Liljefors T, Mayer ML, Egebjerg J, Larsen IK, Gouaux E
J Mol Biol 322 93-109 (2002)
PMID: 12215417

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.21 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand BRH 1 x BRH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P21212
Unit cell:
a: 87.139Å b: 63.681Å c: 47.914Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
20 more