› 1m1l

X-ray diffraction
2.65Å resolution

Human Suppressor of Fused (N-terminal domain)

Released:
DOI: 10.2210/pdb1m1l/pdb
PDB entry 1m1l coloured by chain, front view.
PDB entry 1m1l coloured by chain, side view.
PDB entry 1m1l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Suppressor of fused regulates Gli activity through a dual binding mechanism.
Merchant M, Vajdos FF, Ultsch M, Maun HR, Wendt U, Cannon J, Desmarais W, Lazarus RA, de Vos AM, de Sauvage FJ
Mol Cell Biol 24 8627-41 (2004)
PMID: 15367681

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193976 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Suppressor of fused homolog Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 236 amino acids
Theoretical weight: 26.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UMX1 (Residues: 27-262; Coverage: 49%)
Gene names: SUFU, UNQ650/PRO1280
Sequence domains: Suppressor of fused protein (SUFU)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: R32
Unit cell:
a: 173.025Å b: 173.025Å c: 290.833Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.224 0.256
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Communicating with Hedgehogs.
Hooper et al. (2005)
22 more

7 mentions without citation

Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics.
Zhang et al. (2012)
6 more