› 1lvn

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE COMPLEXED WITH TRANYLCYPROMINE

Released:
DOI: 10.2210/pdb1lvn/pdb
PDB entry 1lvn coloured by chain, front view.
PDB entry 1lvn coloured by chain, side view.
PDB entry 1lvn coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine.
Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE
FEBS Lett 576 301-5 (2004)
PMID: 15498552

Function and Biology Details

Reaction catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155532 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Primary amine oxidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 727 amino acids
Theoretical weight: 81.48 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P46883 (Residues: 31-757; Coverage: 100%)
Gene names: JW1381, b1386, maoA, tynA
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CU 2 x CU
Ligand CA 4 x CA
1 modified residue:
Ligand TYT 2 x TYT

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P212121
Unit cell:
a: 135.236Å b: 166.482Å c: 79.628Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.185 0.229
Expression system: Escherichia coli

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Citations

1 review citation

Gates of enzymes.
Gora et al. (2013)
6 other articles

1 mention without citation

Copper active sites in biology.
Solomon et al. (2014)