› 1lb8

X-ray diffraction
2.3Å resolution

Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with AMPA at 2.3 resolution

Released:
DOI: 10.2210/pdb1lb8/pdb
PDB entry 1lb8 coloured by chain, front view.
PDB entry 1lb8 coloured by chain, side view.
PDB entry 1lb8 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanism of glutamate receptor desensitization.
Sun Y, Olson R, Horning M, Armstrong N, Mayer M, Gouaux E
Nature 417 245-53 (2002)
PMID: 12015593

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 29.27 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand AMQ 2 x AMQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 98.56Å b: 121.376Å c: 47.342Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.218 0.267
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

89 review citations

AMPA receptor trafficking at excitatory synapses.
Bredt et al. (2003)
88 more

4 mentions without citation

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
3 more