› 1k38

X-ray diffraction
1.5Å resolution

CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-2

Released:
DOI: 10.2210/pdb1k38/pdb
PDB entry 1k38 coloured by chain, front view.
PDB entry 1k38 coloured by chain, side view.
PDB entry 1k38 coloured by chain, top view.
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Entry authors: Kerff F, Fonze E, Bouillenne F, Frere JM, Charlier P

Function and Biology Details

Reaction catalysed: 
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141039 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactamase OXA-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 254 amino acids
Theoretical weight: 29.45 KDa
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A1V8 (Residues: 22-275; Coverage: 100%)
Gene names: bla, oxa2
Sequence domains: Penicillin binding protein transpeptidase domain
Structure domains: DD-peptidase/beta-lactamase superfamily

Ligands and Environments

1 bound ligand:
Ligand FMT 3 x FMT
1 modified residue:
Ligand KCX 2 x KCX

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2221
Unit cell:
a: 78.979Å b: 106.899Å c: 129.168Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.198 0.211
Expression system: Escherichia coli

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