› 1j9w

X-ray diffraction
2.6Å resolution

Function and Biology Details

Reactions catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Urea = cyanamide + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133680 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 260 amino acids
Theoretical weight: 28.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00915 (Residues: 2-261; Coverage: 100%)
Gene name: CA1
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE M12X
Spacegroup: P212121
Unit cell:
a: 61.875Å b: 71.732Å c: 120.392Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.311
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Carbonic anhydrase inhibitors.
Supuran et al. (2003)
4 more

2 mentions without citation

Ridge regression estimated linear probability model predictions of O-glycosylation in proteins with structural and sequence data.
Gana et al. (2019)
1 more