› 1ilh

X-ray diffraction
2.76Å resolution

Crystal Structure of Human Pregnane X Receptor Ligand Binding Domain Bound to SR12813

Released:
DOI: 10.2210/pdb1ilh/pdb
PDB entry 1ilh coloured by chain, front view.
PDB entry 1ilh coloured by chain, side view.
PDB entry 1ilh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.
Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR
Science 292 2329-33 (2001)
PMID: 11408620

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 1 group I member 2 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 36.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75469 (Residues: 130-434; Coverage: 70%)
Gene names: NR1I2, PXR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand SRL 1 x SRL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P43212
Unit cell:
a: 91.345Å b: 91.345Å c: 85.302Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.282
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

143 review citations

Clinical importance of the cytochromes P450.
Nebert et al. (2002)
142 more

17 mentions without citation

Role of CAR and PXR in xenobiotic sensing and metabolism.
Wang et al. (2012)
16 more