› 1ic2

X-ray diffraction
2Å resolution

DECIPHERING THE DESIGN OF THE TROPOMYOSIN MOLECULE

Released:
DOI: 10.2210/pdb1ic2/pdb
PDB entry 1ic2 coloured by chain, front view.
PDB entry 1ic2 coloured by chain, side view.
PDB entry 1ic2 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Deciphering the design of the tropomyosin molecule.
Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C
Proc Natl Acad Sci U S A 98 8496-501 (2001)
PMID: 11438684

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137548 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tropomyosin alpha-1 chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 81 amino acids
Theoretical weight: 9.27 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P04268 (Residues: 1-80; Coverage: 28%)
Gene name: TPM1
Sequence domains: Tropomyosin
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P1
Unit cell:
a: 41.4Å b: 45.5Å c: 56.3Å
α: 93.7° β: 98.1° γ: 104.4°
R-values:
R R work R free
0.249 0.249 0.284
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Striated muscle cytoarchitecture: an intricate web of form and function.
Clark et al. (2002)
29 more

22 mentions without citation

A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics.
Lehman et al. (2020)
21 more