› 1i49

X-ray diffraction
2.8Å resolution

CRYSTAL STRUCTURE ANALYSIS OF ARFAPTIN

Released:
DOI: 10.2210/pdb1i49/pdb
PDB entry 1i49 coloured by chain, front view.
PDB entry 1i49 coloured by chain, side view.
PDB entry 1i49 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ
Nature 411 215-9 (2001)
PMID: 11346801

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156792 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arfaptin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 224 amino acids
Theoretical weight: 25.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53365 (Residues: 118-341; Coverage: 66%)
Gene names: ARFIP2, POR1
Sequence domains: Arfaptin-like domain
Structure domains: Arfaptin homology (AH) domain/BAR domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P3221
Unit cell:
a: 146.334Å b: 146.334Å c: 82.732Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.234 0.275
Expression system: Escherichia coli

Quick links

Citations

46 review citations

Local force and geometry sensing regulate cell functions.
Vogel et al. (2006)
45 more

18 mentions without citation

Membrane curvature and its generation by BAR proteins.
Mim et al. (2012)
17 more