› 1hmc

X-ray diffraction
2.5Å resolution

THREE-DIMENSIONAL STRUCTURE OF DIMERIC HUMAN RECOMBINANT MACROPHAGE COLONY STIMULATING FACTOR

Released:
DOI: 10.2210/pdb1hmc/pdb
PDB entry 1hmc coloured by chain, front view.
PDB entry 1hmc coloured by chain, side view.
PDB entry 1hmc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor.
Pandit J, Bohm A, Jancarik J, Halenbeck R, Koths K, Kim SH
Science 258 1358-62 (1992)
PMID: 1455231

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140707 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage colony-stimulating factor 1 43 kDa subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 148 amino acids
Theoretical weight: 17.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09603 (Residues: 36-181; Coverage: 28%)
Gene name: CSF1
Sequence domains: Macrophage colony stimulating factor-1 (CSF-1)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 33.37Å b: 64.75Å c: 157.87Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 not available
Expression system: Not provided

Quick links

Citations

23 review citations

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells.
Zurawski et al. (1994)
22 more

5 mentions without citation

Structure of the active core of human stem cell factor and analysis of binding to its receptor kit.
Jiang et al. (2000)
4 more