Function and Biology Details
Reaction catalysed:
Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Polysaccharide lyase family 8-like, C-terminal
- Chondroitin AC/alginate lyase
- Polysaccharide lyase family 8, C-terminal
- Glycoside hydrolase-type carbohydrate-binding
- Polysaccharide lyase family 8, central domain
- Galactose mutarotase-like domain superfamily
- Polysaccharide lyase 8
- Polysaccharide lyase 8, N-terminal alpha-helical
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Chondroitinase-AC (preferred)
PDBe Complex ID:
PDB-CPX-176789 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Chondroitinase-AC
Molecule details ›
Chain: A
Length: 700 amino acids
Theoretical weight: 79.8 KDa
Source organism: Pedobacter heparinus
Expression system: Pedobacter heparinus
UniProt:
Sequence domains:
Length: 700 amino acids
Theoretical weight: 79.8 KDa
Source organism: Pedobacter heparinus
Expression system: Pedobacter heparinus
UniProt:
- Canonical:
Q59288 (Residues: 1-700; Coverage: 100%)
Sequence domains:
- Polysaccharide lyase family 8, N terminal alpha-helical domain
- Polysaccharide lyase family 8, super-sandwich domain
- Polysaccharide lyase family 8, C-terminal beta-sandwich domain
Ligands and Environments
1 bound ligand:
No modified residues
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X8C
Spacegroup:
P43212
Expression system: Pedobacter heparinus
