› 1hge

X-ray diffraction
2.6Å resolution

BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY

Released:
DOI: 10.2210/pdb1hge/pdb
PDB entry 1hge coloured by chain, front view.
PDB entry 1hge coloured by chain, side view.
PDB entry 1hge coloured by chain, top view.
Source organism: Influenza A virus (A/X-31(H3N2))
Primary publication:
Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Sauter NK, Hanson JE, Glick GD, Brown JH, Crowther RL, Park SJ, Skehel JJ, Wiley DC
Biochemistry 31 9609-21 (1992)
PMID: 1327122

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137032 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Hemagglutinin HA1 chain Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 328 amino acids
Theoretical weight: 36.17 KDa
Source organism: Influenza A virus (A/X-31(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P03438 (Residues: 17-344; Coverage: 60%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Hemagglutinin HA2 chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 175 amino acids
Theoretical weight: 20.21 KDa
Source organism: Influenza A virus (A/X-31(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P03438 (Residues: 346-520; Coverage: 32%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand NAG 12 x NAG
Ligand MNA 3 x MNA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41
Unit cell:
a: 163.1Å b: 163.1Å c: 176.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 not available
Expression system: Not provided

Quick links

Citations

44 review citations

Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin.
Skehel et al. (2000)
43 more

17 mentions without citation

Passive immune neutralization strategies for prevention and control of influenza A infections.
Ye et al. (2012)
16 more