› 1haj

Solution NMR

A beta-Hairpin Structure in a 13-mer Peptide that Binds a-Bungarotoxin with High Affinity and Neutralizes its Toxicity

Released:
DOI: 10.2210/pdb1haj/pdb
PDB entry 1haj coloured by chain, ensemble of 10 models, front view.
PDB entry 1haj coloured by chain, ensemble of 10 models, side view.
PDB entry 1haj coloured by chain, ensemble of 10 models, top view.
Source organisms:
Primary publication:
A beta -hairpin structure in a 13-mer peptide that binds alpha -bungarotoxin with high affinity and neutralizes its toxicity.
Scherf T, Kasher R, Balass M, Fridkin M, Fuchs S, Katchalski-Katzir E
Proc Natl Acad Sci U S A 98 6629-34 (2001)
PMID: 11381118

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158063 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Alpha-bungarotoxin Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.01 KDa
Source organism: Bungarus multicinctus
UniProt:
  • Canonical: P60615 (Residues: 22-95; Coverage: 100%)
Structure domains: CD59
PEPTIDE Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.71 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY, DYNAMICAL SIMULATED ANNEALING
Expression system: Not provided

Quick links

Citations

6 review citations

Exploring protein-protein interactions with phage display.
Sidhu et al. (2003)
5 more

2 mentions without citation

A beta -hairpin structure in a 13-mer peptide that binds alpha -bungarotoxin with high affinity and neutralizes its toxicity.
Scherf et al. (2001)
1 more