› 1gzw

X-ray diffraction
1.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140623 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Galectin-1 Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 14.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09382 (Residues: 2-135; Coverage: 99%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls
Galectin-1 Chain: B
Molecule details ›
Chain: B
Length: 134 amino acids
Theoretical weight: 14.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09382 (Residues: 2-135; Coverage: 99%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL
Carbohydrate polymer
2 bound ligands:
Ligand BME 5 x BME
Ligand SO4 1 x SO4
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup: P212121
Unit cell:
a: 36.979Å b: 88.805Å c: 93.944Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.237
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Galectin-1: a small protein with major functions.
Camby et al. (2006)
24 more

31 mentions without citation

Galectins as Molecular Targets for Therapeutic Intervention.
Dings et al. (2018)
30 more