› 1egg

X-ray diffraction
2.3Å resolution

STRUCTURE OF A C-TYPE CARBOHYDRATE-RECOGNITION DOMAIN (CRD-4) FROM THE MACROPHAGE MANNOSE RECEPTOR

Released:
DOI: 10.2210/pdb1egg/pdb
PDB entry 1egg coloured by chain, front view.
PDB entry 1egg coloured by chain, side view.
PDB entry 1egg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor.
Feinberg H, Park-Snyder S, Kolatkar AR, Heise CT, Taylor ME, Weis WI
J Biol Chem 275 21539-48 (2000)
PMID: 10779515

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149837 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage mannose receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 147 amino acids
Theoretical weight: 16.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22897 (Residues: 642-788; Coverage: 10%)
Gene names: CLEC13D, CLEC13DL, MRC1, MRC1L1
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: C2
Unit cell:
a: 129.89Å b: 38.28Å c: 54.81Å
α: 90° β: 99.09° γ: 90°
R-values:
R R work R free
0.216 0.216 0.278
Expression system: Escherichia coli

Quick links

Citations

9 review citations

The C-type lectin-like domain superfamily.
Zelensky et al. (2005)
8 more

4 mentions without citation

Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206.
Feinberg et al. (2021)
3 more