› 1ebo

X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF THE EBOLA VIRUS MEMBRANE-FUSION SUBUNIT, GP2, FROM THE ENVELOPE GLYCOPROTEIN ECTODOMAIN

Released:
DOI: 10.2210/pdb1ebo/pdb
PDB entry 1ebo coloured by chain, front view.
PDB entry 1ebo coloured by chain, side view.
PDB entry 1ebo coloured by chain, top view.
Source organism: Ebola virus sp.
Primary publication:
Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain.
Weissenhorn W, Carfí A, Lee KH, Skehel JJ, Wiley DC
Mol Cell 2 605-16 (1998)
PMID: 9844633

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assemblies composition:
homo trimer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-126731 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Shed GP Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 131 amino acids
Theoretical weight: 15.36 KDa
Source organism: Ebola virus sp.
Expression system: Escherichia coli
UniProt:
  • Canonical: O11457 (Residues: 540-650; Coverage: 17%)
Gene name: GP
Structure domains: Helix Hairpins

Ligands and Environments

2 bound ligands:
Ligand ZN 3 x ZN
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-13
Spacegroup: C2
Unit cell:
a: 171.702Å b: 32.691Å c: 168.863Å
α: 90° β: 119.23° γ: 90°
R-values:
R R work R free
0.239 0.239 0.256
Expression system: Escherichia coli

Quick links

Citations

62 review citations

Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin.
Skehel et al. (2000)
61 more

22 mentions without citation

Virus membrane fusion.
Weissenhorn et al. (2007)
21 more