› 1e5a

X-ray diffraction
1.8Å resolution

Structure of human transthyretin complexed with bromophenols: a new mode of binding

Released:
DOI: 10.2210/pdb1e5a/pdb
PDB entry 1e5a coloured by chain, front view.
PDB entry 1e5a coloured by chain, side view.
PDB entry 1e5a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human transthyretin complexed with bromophenols: a new mode of binding.
Ghosh M, Meerts IA, Cook A, Bergman A, Brouwer A, Johnson LN
Acta Crystallogr D Biol Crystallogr 56 1085-95 (2000)
PMID: 10957627

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand TBP 2 x TBP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21212
Unit cell:
a: 42.8Å b: 84.9Å c: 64.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.262

Quick links

Citations

6 review citations

Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.
Hou et al. (2007)
5 more

3 mentions without citation

Stretching to understand proteins - a survey of the protein data bank.
SuĊ‚kowska et al. (2008)
2 more