› 1d2s

X-ray diffraction
1.55Å resolution

CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE

Released:
DOI: 10.2210/pdb1d2s/pdb
PDB entry 1d2s coloured by chain, front view.
PDB entry 1d2s coloured by chain, side view.
PDB entry 1d2s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain.
Grishkovskaya I, Avvakumov GV, Sklenar G, Dales D, Hammond GL, Muller YA
EMBO J 19 504-12 (2000)
PMID: 10675319

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137579 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sex hormone-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 18.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04278 (Residues: 42-217; Coverage: 46%)
Gene name: SHBG
Sequence domains: Laminin G domain
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand DHT 1 x DHT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: R32
Unit cell:
a: 104.04Å b: 104.04Å c: 84.43Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.205 0.251
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model.
Norman et al. (2004)
22 more

22 mentions without citation

Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain.
Grishkovskaya et al. (2000)
21 more