› 1d2l

Solution NMR

NMR SOLUTION STRUCTURE OF COMPLEMENT-LIKE REPEAT CR3 FROM THE LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN (LRP). EVIDENCE FOR SPECIFIC BINDING TO THE RECEPTOR BINDING DOMAIN OF HUMAN ALPHA-2 MACROGLOBULIN

Released:
DOI: 10.2210/pdb1d2l/pdb
PDB entry 1d2l coloured by chain, ensemble of 20 models, front view.
PDB entry 1d2l coloured by chain, ensemble of 20 models, side view.
PDB entry 1d2l coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin.
Dolmer K, Huang W, Gettins PG
J Biol Chem 275 3264-9 (2000)
PMID: 10652313

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170571 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor-related protein 1 515 kDa subunit Chain: A
Molecule details ›
Chain: A
Length: 45 amino acids
Theoretical weight: 4.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07954 (Residues: 851-893; Coverage: 1%)
Gene names: A2MR, APR, LRP1
Sequence domains: Low-density lipoprotein receptor domain class A
Structure domains: Low-density Lipoprotein Receptor

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: MOLECULAR DYNAMICS ENERGY MINIMIZATION
Expression system: Escherichia coli

Quick links

Citations

5 review citations

LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.
Lillis et al. (2008)
4 more

4 mentions without citation

The cellular receptor to human rhinovirus 2 binds around the 5-fold axis and not in the canyon: a structural view.
Hewat et al. (2000)
3 more