› 1cq0

Solution NMR

SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B'SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B '

Released:
DOI: 10.2210/pdb1cq0/pdb
PDB entry 1cq0 coloured by chain, front view.
PDB entry 1cq0 coloured by chain, side view.
PDB entry 1cq0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B.
Lee JH, Bang E, Chae KJ, Kim JY, Lee DW, Lee W
Eur J Biochem 266 831-9 (1999)
PMID: 10583376

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129028 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Orexin-B Chain: A
Molecule details ›
Chain: A
Length: 28 amino acids
Theoretical weight: 2.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43612 (Residues: 71-97; Coverage: 28%)
Gene names: HCRT, OX, PPORX, PPOX

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing

Quick links

Citations

22 review citations

The hypocretins: setting the arousal threshold.
Sutcliffe et al. (2002)
21 more

3 mentions without citation

A genetically encoded sensor for in vivo imaging of orexin neuropeptides.
Duffet et al. (2022)
2 more