Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Erythropoietin and Erythropoietin receptor (preferred)
PDBe Complex ID:
PDB-CPX-134423 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Erythropoietin receptor
Molecule details ›
Chains: A, B
Length: 228 amino acids
Theoretical weight: 25.27 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
Sequence domains:
Structure domains: Immunoglobulins
Length: 228 amino acids
Theoretical weight: 25.27 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
- Canonical:
P19235 (Residues: 24-249; Coverage: 47%)
Sequence domains:
Structure domains: Immunoglobulins
Erythropoietin
Molecule details ›
Chain: C
Length: 166 amino acids
Theoretical weight: 18.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Erythropoietin/thrombopoietin
Structure domains: Growth Hormone; Chain: A;
Length: 166 amino acids
Theoretical weight: 18.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P01588 (Residues: 28-193; Coverage: 100%)
Sequence domains: Erythropoietin/thrombopoietin
Structure domains: Growth Hormone; Chain: A;
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU RU200
Spacegroup:
P212121
Expression systems:
- Komagataella pastoris
- Escherichia coli
