› 1ccf

Solution NMR

How an Epidermal Growth Factor (EGF)-Like Domain Binds Calcium-High Resolution NMR Structure of the Calcium Form of the NH2-Terminal EGF-Like Domain in Coagulation Factor X

Released:
DOI: 10.2210/pdb1ccf/pdb
PDB entry 1ccf coloured by chain, ensemble of 15 models, front view.
PDB entry 1ccf coloured by chain, ensemble of 15 models, side view.
PDB entry 1ccf coloured by chain, ensemble of 15 models, top view.
Source organism: Bos taurus
Primary publication:
How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X.
Selander-Sunnerhagen M, Ullner M, Persson E, Teleman O, Stenflo J, Drakenberg T
J Biol Chem 267 19642-9 (1992)
PMID: 1527084

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133220 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Factor X light chain Chain: A
Molecule details ›
Chain: A
Length: 42 amino acids
Theoretical weight: 4.58 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P00743 (Residues: 85-126; Coverage: 9%)
Gene name: F10
Sequence domains: EGF-like domain
Structure domains: Laminin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand BH2 1 x BH2

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

15 review citations

Exposure of platelet membrane phosphatidylserine regulates blood coagulation.
Lentz BR. (2003)
14 more