› 1c1s

X-ray diffraction
1.63Å resolution

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES

Released:
DOI: 10.2210/pdb1c1s/pdb
PDB entry 1c1s coloured by chain, front view.
PDB entry 1c1s coloured by chain, side view.
PDB entry 1c1s coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases.
Katz BA, Luong C
J Mol Biol 292 669-84 (1999)
PMID: 10497030

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Arg-|-, Lys-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease 1 Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.32 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00760 (Residues: 24-246; Coverage: 97%)
Gene names: PRSS1, TRP1, TRY1, TRYP1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

4 bound ligands:
Ligand CA 1 x CA
Ligand NA 1 x NA
Ligand PO4 3 x PO4
Ligand BAB 1 x BAB
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3121
Unit cell:
a: 55.35Å b: 55.35Å c: 109.8Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.185 0.206

Quick links

Citations

1 review citation

Redox control of protein degradation.
Lockwood TD. (2000)
16 other articles