› 1br9

X-ray diffraction
2.1Å resolution

HUMAN TISSUE INHIBITOR OF METALLOPROTEINASE-2

Released:
DOI: 10.2210/pdb1br9/pdb
PDB entry 1br9 coloured by chain, front view.
PDB entry 1br9 coloured by chain, side view.
PDB entry 1br9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution.
Tuuttila A, Morgunova E, Bergmann U, Lindqvist Y, Maskos K, Fernandez-Catalan C, Bode W, Tryggvason K, Schneider G
J Mol Biol 284 1133-40 (1998)
PMID: 9837731

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147586 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metalloproteinase inhibitor 2 Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 21.78 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P16035 (Residues: 27-220; Coverage: 100%)
Gene name: TIMP2
Sequence domains: Tissue inhibitor of metalloproteinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21212
Unit cell:
a: 72.05Å b: 52.7Å c: 46.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.238 0.271
Expression system: Trichoplusia ni

Quick links

Citations

13 review citations

Matrix metalloproteinases.
Nagase et al. (1999)
12 more

27 mentions without citation

Tissue inhibitor of metalloproteinases-4. The road less traveled.
Melendez-Zajgla et al. (2008)
26 more